Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function.

Lo, Wan-Lin; Kuhlmann, Miriam; Rizzuto, Gabrielle; Ekiz, H Atakan; Kolawole, Elizabeth M; Revelo, Monica P; Andargachew, Rakieb; Li, Zhongmei; Tsai, Yuan-Li; Marson, Alexander; Evavold, Brian D; Zehn, Dietmar; Weiss, Arthur.

Nat Immunol ; 24(4): 676-689, 2023 04.

Artigo em Inglês | MEDLINE | ID: mdl-36914891

2.

Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development.

Scherer, Stefanie; Oberle, Susanne G; Kanev, Kristiyan; Gerullis, Ann-Katrin; Wu, Ming; de Almeida, Gustavo P; Puleston, Daniel J; Baixauli, Francesc; Aly, Lilian; Greco, Alessandro; Nizharadze, Tamar; Becker, Nils B; Hoesslin, Madlaina V; Donhauser, Lara V; Berner, Jacqueline; Chu, Talyn; McNamara, Hayley A; Esencan, Zeynep; Roelli, Patrick; Wurmser, Christine; Kleiter, Ingo; Vehreschild, Maria J G T; Mayer, Christoph A; Knolle, Percy; Klingenspor, Martin; Fumagalli, Valeria; Iannacone, Matteo; Prlic, Martin; Korn, Thomas; Pearce, Erika L; Höfer, Thomas; Schulz, Anna M; Zehn, Dietmar.

Nat Immunol ; 24(3): 501-515, 2023 03.

Artigo em Inglês | MEDLINE | ID: mdl-36797499

3.

'Stem-like' precursors are the fount to sustain persistent CD8⁺ T cell responses.

Zehn, Dietmar; Thimme, Robert; Lugli, Enrico; de Almeida, Gustavo Pereira; Oxenius, Annette.

Nat Immunol ; 23(6): 836-847, 2022 06.

Artigo em Inglês | MEDLINE | ID: mdl-35624209

4.

Beta cell-specific CD8⁺ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes.

Abdelsamed, Hossam A; Zebley, Caitlin C; Nguyen, Hai; Rutishauser, Rachel L; Fan, Yiping; Ghoneim, Hazem E; Crawford, Jeremy Chase; Alfei, Francesca; Alli, Shanta; Ribeiro, Susan Pereira; Castellaw, Ashley H; McGargill, Maureen A; Jin, Hongjian; Boi, Shannon K; Speake, Cate; Serti, Elisavet; Turka, Laurence A; Busch, Michael E; Stone, Mars; Deeks, Steven G; Sekaly, Rafick-Pierre; Zehn, Dietmar; James, Eddie A; Nepom, Gerald T; Youngblood, Ben.

Nat Immunol ; 21(5): 578-587, 2020 05.

Artigo em Inglês | MEDLINE | ID: mdl-32231298

5.

Stat5a sobers up inTOXicated T cells.

Donhauser, Lara V; Zehn, Dietmar.

Immunity ; 56(12): 2670-2672, 2023 Dec 12.

Artigo em Inglês | MEDLINE | ID: mdl-38091945

6.

The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1⁺ CD8⁺ T cells in chronic viral infection.

Marx, Anna-Friederike; Kallert, Sandra M; Brunner, Tobias M; Villegas, José A; Geier, Florian; Fixemer, Jonas; Abreu-Mota, Tiago; Reuther, Peter; Bonilla, Weldy V; Fadejeva, Jelizaveta; Kreutzfeldt, Mario; Wagner, Ingrid; Aparicio-Domingo, Patricia; Scarpellino, Leo; Charmoy, Mélanie; Utzschneider, Daniel T; Hagedorn, Claudia; Lu, Min; Cornille, Karen; Stauffer, Karsten; Kreppel, Florian; Merkler, Doron; Zehn, Dietmar; Held, Werner; Luther, Sanjiv A; Löhning, Max; Pinschewer, Daniel D.

Immunity ; 56(4): 813-828.e10, 2023 04 11.

Artigo em Inglês | MEDLINE | ID: mdl-36809763

7.

Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches.

Dähling, Sabrina; Mansilla, Ana Maria; Knöpper, Konrad; Grafen, Anika; Utzschneider, Daniel T; Ugur, Milas; Whitney, Paul G; Bachem, Annabell; Arampatzi, Panagiota; Imdahl, Fabian; Kaisho, Tsuneyasu; Zehn, Dietmar; Klauschen, Frederick; Garbi, Natalio; Kallies, Axel; Saliba, Antoine-Emmanuel; Gasteiger, Georg; Bedoui, Sammy; Kastenmüller, Wolfgang.

Immunity ; 55(4): 656-670.e8, 2022 04 12.

Artigo em Inglês | MEDLINE | ID: mdl-35366396

8.

An adrenaline kick to exhaust T cells.

Berner, Jacqueline; Zehn, Dietmar.

Nat Immunol ; 24(11): 1792-1793, 2023 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-37813966

9.

Tapping the keg of discovery to advance T cell therapy.

Schulz, Anna M; Zebley, Caitlin C; Youngblood, Ben; Zehn, Dietmar.

Nat Immunol ; 24(2): 213-215, 2023 02.

Artigo em Inglês | MEDLINE | ID: mdl-36631639

10.

PGE₂ limits effector expansion of tumour-infiltrating stem-like CD8⁺ T cells.

Lacher, Sebastian B; Dörr, Janina; de Almeida, Gustavo P; Hönninger, Julian; Bayerl, Felix; Hirschberger, Anna; Pedde, Anna-Marie; Meiser, Philippa; Ramsauer, Lukas; Rudolph, Thomas J; Spranger, Nadine; Morotti, Matteo; Grimm, Alizee J; Jarosch, Sebastian; Oner, Arman; Gregor, Lisa; Lesch, Stefanie; Michaelides, Stefanos; Fertig, Luisa; Briukhovetska, Daria; Majed, Lina; Stock, Sophia; Busch, Dirk H; Buchholz, Veit R; Knolle, Percy A; Zehn, Dietmar; Dangaj Laniti, Denarda; Kobold, Sebastian; Böttcher, Jan P.

Nature ; 629(8011): 417-425, 2024 May.

Artigo em Inglês | MEDLINE | ID: mdl-38658748

11.

Charting the Roadmap of T Cell Exhaustion.

Chu, Talyn; Zehn, Dietmar.

Immunity ; 52(5): 724-726, 2020 05 19.

Artigo em Inglês | MEDLINE | ID: mdl-32433943

12.

Functional T cells are capable of supernumerary cell division and longevity.

Soerens, Andrew G; Künzli, Marco; Quarnstrom, Clare F; Scott, Milcah C; Swanson, Lee; Locquiao, J J; Ghoneim, Hazem E; Zehn, Dietmar; Youngblood, Benjamin; Vezys, Vaiva; Masopust, David.

Nature ; 614(7949): 762-766, 2023 02.

Artigo em Inglês | MEDLINE | ID: mdl-36653453

13.

MYB orchestrates T cell exhaustion and response to checkpoint inhibition.

Tsui, Carlson; Kretschmer, Lorenz; Rapelius, Svenja; Gabriel, Sarah S; Chisanga, David; Knöpper, Konrad; Utzschneider, Daniel T; Nüssing, Simone; Liao, Yang; Mason, Teisha; Torres, Santiago Valle; Wilcox, Stephen A; Kanev, Krystian; Jarosch, Sebastian; Leube, Justin; Nutt, Stephen L; Zehn, Dietmar; Parish, Ian A; Kastenmüller, Wolfgang; Shi, Wei; Buchholz, Veit R; Kallies, Axel.

Nature ; 609(7926): 354-360, 2022 09.

Artigo em Inglês | MEDLINE | ID: mdl-35978192

14.

Two parallel worlds of memory T cells.

Chu, Talyn; Berner, Jacqueline; Zehn, Dietmar.

Nat Immunol ; 21(12): 1484-1485, 2020 12.

Artigo em Inglês | MEDLINE | ID: mdl-33116302

15.

Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8⁺ T Cells.

Page, Nicolas; Klimek, Bogna; De Roo, Mathias; Steinbach, Karin; Soldati, Hadrien; Lemeille, Sylvain; Wagner, Ingrid; Kreutzfeldt, Mario; Di Liberto, Giovanni; Vincenti, Ilena; Lingner, Thomas; Salinas, Gabriela; Brück, Wolfgang; Simons, Mikael; Murr, Rabih; Kaye, Jonathan; Zehn, Dietmar; Pinschewer, Daniel D; Merkler, Doron.

Immunity ; 48(5): 937-950.e8, 2018 05 15.

Artigo em Inglês | MEDLINE | ID: mdl-29768177

16.

Auto-aggressive CXCR6⁺ CD8 T cells cause liver immune pathology in NASH.

Dudek, Michael; Pfister, Dominik; Donakonda, Sainitin; Filpe, Pamela; Schneider, Annika; Laschinger, Melanie; Hartmann, Daniel; Hüser, Norbert; Meiser, Philippa; Bayerl, Felix; Inverso, Donato; Wigger, Jennifer; Sebode, Marcial; Öllinger, Rupert; Rad, Roland; Hegenbarth, Silke; Anton, Martina; Guillot, Adrien; Bowman, Andrew; Heide, Danijela; Müller, Florian; Ramadori, Pierluigi; Leone, Valentina; Garcia-Caceres, Cristina; Gruber, Tim; Seifert, Gabriel; Kabat, Agnieszka M; Mallm, Jan-Philipp; Reider, Simon; Effenberger, Maria; Roth, Susanne; Billeter, Adrian T; Müller-Stich, Beat; Pearce, Edward J; Koch-Nolte, Friedrich; Käser, Rafael; Tilg, Herbert; Thimme, Robert; Boettler, Tobias; Tacke, Frank; Dufour, Jean-Francois; Haller, Dirk; Murray, Peter J; Heeren, Ron; Zehn, Dietmar; Böttcher, Jan P; Heikenwälder, Mathias; Knolle, Percy A.

Nature ; 592(7854): 444-449, 2021 04.

Artigo em Inglês | MEDLINE | ID: mdl-33762736

17.

Transcription Factor IRF4 Promotes CD8⁺ T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection.

Man, Kevin; Gabriel, Sarah S; Liao, Yang; Gloury, Renee; Preston, Simon; Henstridge, Darren C; Pellegrini, Marc; Zehn, Dietmar; Berberich-Siebelt, Friederike; Febbraio, Mark A; Shi, Wei; Kallies, Axel.

Immunity ; 47(6): 1129-1141.e5, 2017 12 19.

Artigo em Inglês | MEDLINE | ID: mdl-29246443

18.

T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion.

Utzschneider, Daniel T; Legat, Amandine; Fuertes Marraco, Silvia A; Carrié, Lucie; Luescher, Immanuel; Speiser, Daniel E; Zehn, Dietmar.

Nat Immunol ; 14(6): 603-10, 2013 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-23644506

19.

T Cell Factor 1-Expressing Memory-like CD8(+) T Cells Sustain the Immune Response to Chronic Viral Infections.

Utzschneider, Daniel T; Charmoy, Mélanie; Chennupati, Vijaykumar; Pousse, Laurène; Ferreira, Daniela Pais; Calderon-Copete, Sandra; Danilo, Maxime; Alfei, Francesca; Hofmann, Maike; Wieland, Dominik; Pradervand, Sylvain; Thimme, Robert; Zehn, Dietmar; Held, Werner.

Immunity ; 45(2): 415-27, 2016 08 16.

Artigo em Inglês | MEDLINE | ID: mdl-27533016

20.

TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection.

Alfei, Francesca; Kanev, Kristiyan; Hofmann, Maike; Wu, Ming; Ghoneim, Hazem E; Roelli, Patrick; Utzschneider, Daniel T; von Hoesslin, Madlaina; Cullen, Jolie G; Fan, Yiping; Eisenberg, Vasyl; Wohlleber, Dirk; Steiger, Katja; Merkler, Doron; Delorenzi, Mauro; Knolle, Percy A; Cohen, Cyrille J; Thimme, Robert; Youngblood, Benjamin; Zehn, Dietmar.

Nature ; 571(7764): 265-269, 2019 07.

Artigo em Inglês | MEDLINE | ID: mdl-31207605

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